Epigenetic differences when considering mobile contours correlate with differences in A beneficial/B compartmentalization
Just like the CTCF Chip-seq study was designed for half dozen cellphone lines which have Hello–C investigation, we could systematically do this analysis for it basis
As the A compartment is associated with open state of the chromatin we next systematically examined the association between A/B compartmentalization and TF binding. We analyzed 122 TF ChIP-seq datasets recorded by ENCODE for cell lines with Hi–C data (Additional file 1: Table S2). First, we measured TF binding site (TFBS) enrichment for the A compartment, for each cell line separately, by defining the A–B density factor, D (D > 1 (positive in log scale) implies that binding sites are enriched for the A compartment and D < 1 (negative in log scale) implies that binding sites are enriched for B compartment; “Methods” section). As expected, the chromatin-binding profile of all TFs in all examined cell lines showed a remarkable enrichment for the A compartment (Additional file 2: Fig. S3; see Additional file 1: Table S3 for one detailed example: CTCF).
I after that checked-out getting a love between those two divisions
Second, i tested whether Good–B changes ranging from mobile contours is mirrored by TF joining profiles.